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This locoregional delivery of CAR-T cells with a medium-length CAR spacer increases the therapeutic efficacy of HER2-CAR T cells in an orthotopic xenograft model with the cell lines D283-Med and Med411FH, but not against the HER2-negative D431 cell line (234)

Conclusion: Serum CHI3L1 levels decreased significantly during antiviral therapy in treatment-nave CHB patients with liver fibrosis, a 20% decrease at 52 weeks could be a potential non-invasive surrogate marker of liver fibrosis regression