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High-energy diets are now widely fed to farmed fish, which has led to a number of metabolic diseases, especially severe fat accumulation, developing in various fish species, leading to adverse effects on their growth and health ( Reference Wang, Liu and Tian 25 , Reference Du, Clouet and Huang 26 )

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Additional measurements of metabolic parameters in one monkey and three rats revealed rapid clearance of DSIP from plasma, with half-lives of 2.9 and 2.0 +/- 0.54 minutes, respectively