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Targeting p53 in vivo : a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

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Since urine pH is directly related to renal injury, in patients receiving MTX treatments, low urine pH in the early stages of treatment is a substantial independent risk factor for MTX-induced nephrotoxicity (Kawaguchi et al

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3.5 CB-839 induces autophagy in CLL cell lines Because glutamine flux regulates mammalian target of rapamycin complex 1s kinase activity, which is responsible for autophagy, we assessed the effects of glutaminase inhibition on autophagy as an alternative mechanism of CB-839mediated cell death ( Figure 4A )

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