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Synthesis of linear and cyclic peptides using the Ddz strategy Synthesis of linear peptide with Seg.Id.No: 4 Synthesis of cyclic peptide with Seg.Id.No: 9 Claims (16) A peptide consisting of 8 to 15 amino acid residues which is represented by the general formula:Xaa signifies a neutral aliphatic amino acid residue like Ala, bAla, Leu, Ile, Gly, Val, Nle, NvaYaa signifies a basic amino acid residue like Lys, Arg, Orn, His,Zaa signifies an acidic amino acid residue like Glu, Asp, Aad or Apm;wherein at least one of residues Xaa or Zaa can be omitted

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On the other hand, Repatha (evolocumab, Amgen) used the Pushtronex system (Wests SmartDose) and Ultomiris (ravulizumab, Alexion) also used SmartDose to deliver 3.5 mL of solution

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