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Endocrinology 152 , 36383647 (2011)

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Furthermore, integration of advanced manufacturing (GMP-compatible processes, scalable encapsulation techniques), quantitative multi-omics and mechanistic studies (metagenomics, metabolomics, host transcriptomics), and standardized safety assessments will be essential for clinical translation

smallpox vaccine is highly effective from the acute administration within seven days of likely exposure, among those that can safely take the vaccine and are assuredly within the 7 days, means that uninfected, or perhaps even the early-infected cell populations, can rapidly produce sufficient quantities of IL-12, IL-18, IFNy, and factors to stimulate NK cells, and Variola-specific CTL's to overcome the viral evasion proteins and stop the infection in this early phase