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Plays a key role in maintaining healthy nervous system function and supports the formation of myelin sheaths that protect nerve fibers

Circulating monocytes are recruited to sites of inflammation by cell adhesion molecules and chemoattractants, which are known to be upregulated at baseline in G6PD-d 28,29

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Upon activation by conditions inducing ER stress, CHAC1 expression is upregulated primarily through the PERK-eIF2-ATF3/4 signaling pathway, independent of other UPR branches like IRE1-XBP1