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It was a first report showing a nanozymes catalyzing a two-step hydrolysis reaction with a faster catalytic rate (t 1/2 value of 1.2 and 3.5 min for methyl paraoxon and methyl parathion hydrolysis, respectively) than the single-step hydrolysis reaction reported earlier by others

RSL3, a ferroptosis inducer, directly acts on GPX4 and inhibits its activity, thus reducing the antioxidant capacity of cells and accumulating ROS, leading to ferroptosis 12

The ligand was spiked out of the protein at 60ns, and then it rejoined the protein at 90ns with major fluctuation (1048)

Ravna AW et al (2009): Structure and localisation of drug binding sites on neurotransmitter transporters