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This intrinsic oxidative vulnerability of the brain and growing evidence of neurodegenerative changes associated with many psychiatric syndromes suggests that oxidative damage may be a plausible pathogenic candidate

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(DAT, NET, and SERT) 2) By utilizing these transporters for its own uptake, amphetamine directly competes with endogenous dopamine, norepinephrine, and serotonin, thereby inhibiting their clearance from the synaptic cleft (Martin & Le, 2023)