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doi: 10.1084/jem.20140857 46 DrijversJMGillisJEMuijlwijkTNguyenTHGaudianoEFHarrisISet al

113, E2705E2713

Significance was determined using a 2-tailed Students t test, unless otherwise specified in figure legends

The molecule's central position in glycolysis, gluconeogenesis, and fatty acid oxidation means that NAD+ availability directly influences metabolic flux and energy homeostasis