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In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)

5 Disorder associated with PD Some disorders associated with PD are shown in Figure 2

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Therefore, various antioxidants, including sulforaphane (229), resveratrol (230233), N-acetylcysteine (NAC) (234, 235), hesperidin (236), flavonoid (237, 238), leptin (239), minocycline, and doxycycline (240), selenium supplements (241), docosahexaenoic acid (DHA) (242), curcumin (243), agmatine (244), and sulindac (245), etc., have been reported to be employed in ASD treatment animal model experiments