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Implications for discovery of new FeS proteins Discovery of the important role for LYR motifs opens the possibility that informatics can be used to identify prospective FeS proteins, and feasible follow-up steps including analysis by ICP-MS followed by scale up for analysis by definitive techniques that require large amounts of protein such as EPR and Mossbauer could revolutionize FeS protein discovery and lead to revision of many metabolic pathways (Rouault 2015a, b)

Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight

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Balancing act: NRF2s contradictory roles in cancer progression and therapy