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[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation

Research shows that these patients face a 2- to 3-fold increased risk of gastric adenocarcinoma and type I gastric carcinoid tumors linked to chronic atrophic gastritis and achlorhydria