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Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury

Srinivasan P, Fujioka H, Jacobs-Lorena M (2008) PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito

The specific mechanisms and therapeutic effects will be elaborated on in detail in the treatment section that follows

In another aspect, the present invention broadly consists in a method of making an amino acid- or peptide conjugate of the formula (I) or a pharmaceutically acceptable salt or solvate thereof of the present invention, the method comprising reacting a first lipid-containing conjugation partner comprising a carbon-carbon double bond, a second lipid-containing conjugation partner comprising a carbon-carbon double bond, and an amino acid-comprising conjugation partner comprising a thiol under conditions effective to conjugate the first lipid-containing conjugation partner and the second lipid-containing conjugation partner to the amino acid-comprising conjugation partner and provide the amino acid or peptide-conjugate of formula (I) or salt or solvate thereof, wherein in the amino acid- or peptide conjugate the sulfur atom from the thiol of the amino acid-comprising conjugation partner is conjugated to a carbon atom from the carbon-carbon double bond of the first lipid-containing conjugation partner, and a carbon atom from the carbon-carbon double bond of the first lipid-containing conjugation partner is conjugated to a carbon atom from the carbon-carbon double bond of the second lipid-containing conjugation partner