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Cagrilintide works through an entirely separate system, the amylin receptor pathway, targeting different neuronal populations in the brainstem that regulate satiety and appetite

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This difference is likely to be related to the more tightly packed ECD interface of RAMP2 and CTR, driven by the interactions with P37 Cagri , and the preferential CTR engagement by Cagri via a bypass conformation, as discussed below in the context of CTR complexes

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