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In IDH1 mutant glioblastoma, BCAT1 is transcriptionally suppressed because of the hypermethylation of three CpGs in the promoter, and this is also the consequence of IDH1 mutation-induced 2-hydroxyglutarate (2-HG) (Tonjes et al., 2013)

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68 Moreover, zinc released from the synapse directly activates a G-protein coupled receptor (mZnR/GPR39), sensing changes in extracellular zinc concentration and consequently regulating neuronal excitation

The independent acclimation mechanisms detected might explain why results from laboratory studies often do not match field findings 20,54 and suggest that acclimation capacity is underestimated in laboratory studies that use constant temperatures 37