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Los estudios in vitro emplean tpicamente concentraciones entre 1 nM y 10 M segn el endpoint celular

But B12 is only produced by certain bacteria and microorganisms

In spite of the fact that animal model results are reliable, there is no extensive clinical evidence available

Water concentrations were calculated based on the volume fractions of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF), assuming their water concentrations as 35,880 mM, 43,300 mM, and 55,556 mM, respectively [52]