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Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro : evidence of a thiol mechanism Arch Biochem Biophys 1998 349 : 356362 Yang JP, Merin JP, Nakano T, Kato T, Kitade Y, Okamoto T

conditions of haemochromatosis, haemolytic anaemia and haemodialysis), in the presence of high amounts of H 2 O 2 , heavy metals such as iron (Fe) or copper (Cu) are freed from iron-containing molecules and there is a subsequent interaction of O 2 and H 2 O 2 in a HaberWeiss reaction or Fe 2+ (Cu 2+ )-driven cleavage of H 2 O 2 in a Fenton reaction to generate the highly reactive hydroxyl radical ( OH) as shown in Figure 1 [12,13,16]

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The principal component analysis (PCA) was performed using highly variable genes (HVGs), and the unified manifold approximation and projection (UMAP) was constructed using Louvain algorithm by selecting the first 30 principal components and clustering units