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Description

doi: 10.1002/jcp.27411 91 MajumderMNandiPOmarA

The defining characteristic is the durable growth arrest, typically enforced by the activation of tumor suppressor pathways involving key cell cycle inhibitors like p16 Ink4a (encoded by CDKN2A ) and p21 Cip1 (encoded by CDKN1A ), often acting via p53 and the retinoblastoma protein (pRB) [50, 51]