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Ibuprofen itself can irritate the stomach lining and affect platelet function, which helps blood clot

Meanwhile, evidence indicates that mTOR activation augments tau pathology [352]

Notably, we observed increased BCL-2 protein levels despite significant downregulation of Bcl-2 gene expression, suggesting complex post-transcriptional regulatory mechanisms that may include enhanced protein stability or decreased degradation in response to toxic stress

These situations highlight how hydrogen water can serve not as a replacement for GR but as a strategic complement, particularly valuable when the GR system faces functional limitations or is overwhelmed by excessive oxidative challenges