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6 Tendon injury 6.1 Mechanosensitive calcium pathways and ROS generation in tendon injury Calcium ions (Ca 2+ ) are regulators of tendon cell signaling, acting as key second messengers that mediate processes such as cytoskeletal dynamics, ECM remodeling, oxidative balance, and apoptotic signaling ( via IP 3 and ryanodine receptors, while reuptake is governed by SERCA pumps

Combining our data, we can hypothesise that the Glutathione metabolism pathway may be beneficial in assisting Treg in repairing excess tissue damage during severe IAV infection, helping to maintain the stability of the immune environment

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