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Recent studies have revealed that Cu dyshomeostasis and cuproptosis are intricately linked to the pathological progression of several neurodegenerative diseases, including Alzheimers disease (AD), Parkinsons disease (PD), amyotrophic lateral sclerosis (ALS), Huntingtons disease (HD), Wilsons disease (WD), and Menkes disease (MD)

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However, a manual correction may be applied to determine the global percent identity from a global polypeptide alignment