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In renal tubular epithelial cells treated with calcium oxalate (CaOx) to induce kidney stone formation, CHAC1 expression increases alongside a decreased GSH level, reduced GPX4 activity, increased iron and MDA content and elevated ROS and lipid peroxidation

It impairs absorption of fats, vitamin A, iodine, and lactose digestion and destroys the villi [5], with significant consequences in public health, leading to growth retardation, and cognitive impairment, decreased work capacity, and adverse pregnancy outcomes [6, 7]

10.1111/j.1440-1754.1986.tb00197.x 28

Additionally, a third pathway related to endoplasmic reticulum (ER) stress has also been described (Iurlaro and Munoz-Pinedo, 2016)