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LncRNA CRLA inhibits RIPK1-induced necroptosis by binding to the middle domain of RIPK1, thereby impairing the interaction between RIPK1 and RIPK3 [138]

A., & Zoumpourlis, V

As mentioned above, the cysteine or serine of the catalytic signature is located at the beginning of 1 helix which also contains charged residues involved in the proton transfer reaction