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doi: 10.1093/infdis/jit250 227 ReddyP

We underscore the involvement of T-bet in the pathogenesis of systemic diseases, including autoimmune disorders, infectious diseases, allergic conditions, endocrine disorders, psychiatric illnesses, and chromosomal abnormalities

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For example, patients treated with the 21 hour IV protocol who develop hepatic injury will receive therapy beyond 21 hours and many of the studies evaluating oral administration used variable dosing duration rather than a fixed time