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2 Diuretics: brief historic perspectives 2.1 Thiazides and thiazide-like diuretics Hydrochlorothiazide and chlorthalidone, a benzothiadiazide and a thiazide-like diuretic, respectively were introduced during 1957-59 and the former quickly became a mainstay in the treatment of hypertension

Although TAM itself can be toxic, we observed a rather low mortality rate of 3.7% with a TAM concentration of 100 mg/kg, tested in many adolescent and adult mice (older than 21 days, n = 4,080)

Formulated with 0.9% benzyl alcohol as a preservative, it is designed to help maintain sterility after initial vial entry, making it suitable for multi-use research applications under controlled conditions

Of these 27 articles, 16 were randomized clinical trials or non-randomized controlled observational studies, 6 were systematic reviews or meta-analyses, 3 were reviews of reviews, and 2 were practice guidelines