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gondii show complex response, including reactive remodelling, secretion of interleukins that reduce parasite burden 241,242 and start to produce and release kynurenic acid, which is as an endogenous antagonist of NMDA and acetylcholine receptors

In HGN, pathways such as phenylpropanoid biosynthesis, phenylalanine metabolism, isoflavonoid biosynthesis, fructose and mannose metabolism and inositol phosphate metabolisms were upregulated, while phosphonate metabolism, pyrimidine metabolism, monoterpenoid biosynthesis, glycerolipid metabolism, and amino sugar and nucleotide sugar metabolism were downregulated (Fig

The metabolic state-driven is typically based on metabolome profiling/metabolic state to characterize the antibiotic-resistant metabolome/metabolic state, identify putative metabolic mechanisms underlying antibiotic-resistance, and select critical nutrient metabolites as metabolic reprogramming agents 10,11,12