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Incipient oxidative stress is associated with increased hippocampal protein levels of TOP2 and expression of early response genes (ERGs) While excessive ROS is associated with decreased performance in cognitive function, physiological concentrations of ROS are necessary to regulate activity-dependent neuronal plasticity 67

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Specifically, cytokines secreted by Th1 and Treg cells (e.g., IFN-, IL-2) decrease, while those from Th2 and Th17 cells (endocrine IL-1, IL-4, IL-6) increase, suppressing immune function and promoting apoptosis (150)