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Confocal microscopy revealed a pronounced nuclear-to-cytoplasmic translocation of HMGB1/2-GFP following Hcy or HTL exposure (Figure 5B), with extracellular fluorescence intensity quantification further confirming increased HMGB1/2 secretion (Figure 5C)

Existing studies have confirmed that specific nutrients, including vitamin D, B complex vitamins, and vitamin C, can alleviate mood disorders through enhancing neuroplasticity, regulating homocysteine metabolism, and scavenging free radicals, respectively

Rajesh, Y