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Renal dosing adjustments for adult patients (18 years and older) with cIAI and cUTI with CrCl 50 mL/min or less a,b a,b 30 to 50 CrCl (mL/min) 750 mg (500 mg and 250 mg) intravenously every 8 hours 15 to 29 CrCl (mL/min) 375 mg (250 mg and 125 mg) intravenously every 8 hours For patients with end-stage renal disease (ESRD) on hemodialysis (HD): a single loading dose of 750 mg (500 mg and 250 mg) followed by a 150 mg (100 mg and 50 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis)