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Editor information Editors and Affiliations Rights and permissions Copyright information 2017 Springer Nature Singapore Pte Ltd

ALA or alpha lipoic acid is a powerful antioxidant

Thrombospondin-1 (TSP-1) functions as the first discovered endogenous H 2 S signal inhibitor by binding its receptor CD47 (153)

By reinforcing metabolic ferroptotic axes, enabling paracrine vulnerability, and sustaining chronic inflammation, SASP signaling transforms senescence-associated stress into a self-perpetuating, tissue-wide ferroptotic state