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Temporal Coordination: GH Pulses, Feeding Windows, and Nutrient Flux GH secretory bursts are brief, and their metabolic impact depends on timing relative to nutrient appearance in the circulation

Using redox cycling quinones to increase production of hydrogen peroxide and by measuring transcription by nuclear run-on analysis, it was then shown that a sustained increase the amount of GSH in cells could be achieved by increasing the transcription of GCLC (Shi et al., 1994