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Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Stage IV of B12 deficiency is when the clinical signs and symptoms of it become evident

In vitro COMT inhibition assays demonstrated that the tolcapone-loaded PLGA nanoparticles achieved comparable enzyme inhibition efficacy to free tolcapone, confirming therapeutic retention which was achieved in addition to a controlled-release profile and reduced cytotoxicity