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Description

IGF-1 metabolic actions are partly directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues

showed that CPT II activity is decreased in the liver mitochondria of tumor-bearing cachectic rats [33]

This mechanism may be primarily caused by the deregulation of the Ca 2+ homeostasis induced by the mutation in PSEN1 , as described in PSEN1 mutant AD iPSC-derived astrocytes (Oksanen et al., 2017)