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It is reported that the female-to-male prevalence of ME/CFS in England is 3.88:1, with a peak prevalence of about 6:1 among individuals in the fourth and fifth decades of life [5]

83 Furthermore, R1881 (synthetic androgen) increased the expression and activity of CPTI, the rate-limiting enzyme in the process of mitochondrial FAO, through AR-mediated pathway, leading to increased production of ROS associated with prostate cell proliferation and mutagenesis