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With less estrogen, the lining of the uterus cannot thicken and without a lining to shed, periods stop

Ozdemir BC, Pentcheva-Hoang T

When introduced into living organisms, such as mouse model, siRNA/Ap-CS nanostructures can reach specific tissues and organs by the blood circulation system and enter into target cancer cells by aptamerreceptor interaction without the need of transfection reagents (step IV)

This process can involve gut microbiota metabolites crossing the blood-brain barrier, modulating the microbiota-gut-brain axis, and regulating microglial activity and cytokine release