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Reale, M

Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

doi: 10.1007/s10552-018-1058-4 12

Similarly, TB-500 has undergone extensive safety evaluation including human research trials showing safety at intravenous doses up to 1,260 mg equivalent, with no dose-limiting toxicities or serious adverse events attributable to the peptide in carefully controlled studies