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in vitro effects often fail to translate into clinical effects because many phenolics exhibit poor solubility, instability, and rapid metabolism, which lead to low systemic bioavailability (e.g low levels in the bloodstream) and inadequate tumor exposure ( In this review, redox sensitization refers to a tumor-directed increase in oxidative pressure, or a reduction in tumor antioxidant buffering, sufficient to move malignant cells closer to an apoptotic or therapy-responsive threshold

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Therefore, future research needs to focus on improving the selectivity and efficiency of these delivery mechanisms to improve the treatment outcomes for CNS disorders