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As for those metabolites that contribute to the pathophysiology of the disease, such as UTs and TMAO, future investigations should focus on the development of inhibitors

As a result, senescent microglia secrete a range of SASP components, IL-6, IL-8, MMP3, MMP12, CXCL1, CXCL2, and CXCL10 (Cook et al., 2022)

ix) enantiospecific synthesis from non-racemic precursorsa synthetic technique whereby the desired enantiomer is obtained from non-chiral starting materials and where the stereochemical integrity is not or is only minimally compromised over the course of the synthesis