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In addition, it was previously revealed that knockdown of CHAC1 rescued the cysteine-starvation-induced reduction of glutathione levels and ferroptosis in human breast cancer cell lines (12)

Kerr S-L, Mathew C, Ghildyal R (2021) Rhinovirus and cell death

Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Goncalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV (2017) Adenosine A2A receptors modulate alpha-synuclein aggregation and toxicity

They propose a staging system that takes into account these anchors, and starts from Stage 0, preclinical disease, defined by the presence of fully penetrant SNCA variants