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5.7 Embryo-Fetal Toxicity Based on findings from animal studies and its mechanism of action, pemetrexed for injection can cause fetal harm when administered to a pregnant woman

Li RJ, Qiu SD, Chen HX, Wang LR

The relevance of an appropriate consumption of trace elements such as Se is due to its antioxidant and anti-inflammatory effect, since it has been reported that these patients have an increase in the physiological concentrations of reactive oxygen species (ROS) that can cause damage to cellular components, including proteins, lipids and DNA, that promote the destruction of cartilage and bone [11,12,13]

For instance, a CuO nanoplatform co-loaded with elesclomol potently induces copper-dependent cell death and enhances antitumor immunity