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Using a redox-sensitive fluorescent reporter (Mrx1-roGFP2), flow cytometry, and transcriptomics, we found that macrophages with high oxidative phosphorylation (OXPHOS) and low glycolysis harbor reductive, drug-tolerant Mtb , whereas glycolytically active macrophages generate mitochondrial ROS via reverse electron transport, imposing oxidative stress on Mtb and enhancing drug efficacy

Xu J, Wang Y, Li Y, Yang X, Zhang P, Hou H, et al

For PMP exam prep and real-world projects alike, its important to understand the SD formula, where it applies, and how it supports better decision-making

Zhang XN, Zhao Q, Yang JJ, Wang TX, Chen FB, Zhang K