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Microglial pro-inflammatory polarization is further sustained by altered potassium (KCNJ2, potassium inwardly rectifying channel subfamily J member 2) and calcium (TRPM2, transient receptor potential melastatin 2) channel activity, which regulate cytokine release and immune activation

Some can be run concurrently and some cannot

Treatment with artemisinin, an anti-malarial drug with immune-regulatory and anti-tumor effects, synergizes with anti-PD-L1 therapy in melanoma tumor models, inhibiting MDSC immunosuppression and accumulation and promoting T cell anti-tumor effects (162)

Medication Considerations: Why Your Vet Should Be Involved Medication interactions are one of the most overlooked reasons to involve a veterinarian