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Collectively, these associations reinforce the role of both ingestion and inhalation as dominant exposure pathways, with oxidative and genotoxic mechanisms serving as central drivers of malignancy

Unless there is clear evidence of primary bladder pathology (e.g., small capacity under anesthesia, Hunner lesions), patients should have a multidisciplinary evaluation including assessment for neuropathic pain and psychological profile

Suitable candidates often include middle-aged adults, especially women, and individuals who are overweight or engage in prolonged standing or high-impact activities

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