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In addition to their contractile function, VSMCs possess biosynthetic and proliferative capabilities that contribute to vessel wall homeostasis [21]

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Piperlongumine Piperlongumine (PL) is an alkaloid isolated from Piper species, commonly used in traditional medicine in particular in Asia and Latin America that in recent years has been extensively studied because of its anti-cancer potential, being able to inhibit proliferation in several cancer cell lines 107

Sosne, G., et al