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Mitochondria are critical for muscle function and although we have reported defects in muscle mitochondrial respiration during early cognitive decline, APOE4 -mediated effects on muscle mitochondria are unknown

Endothelial cells in the BBB also express a variety of efflux transporter proteins that drain various lipophilic molecules from the brain back into the bloodstream[19]

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Seizures in these cases may present as spastic seizures, status epilepticus, focal non-convulsive status epilepticus, or generalized tonicclonic seizures (83, 84)