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In the mitochondrial sulfide oxidation pathway, SQOR, a flavin adenine dinucleotide (FAD)-dependent enzyme, initiates H 2 S oxidation coupled with the reduction of coenzyme Q (CoQ or ubiquinone) ( 2 ), which subsequently reduces CoQ

(3) Within the nerve terminal, ephedrine displaces norepinephrine from a finite pool of synaptic vesicles in the readily releasable pool, resulting in norepinephrine release into the synaptic cleft through reverse NET transport (rNET)

eLife 9 , e54870 (2020)

Knockout of HGMB1 promoted the expression of NRF2 and its downstream targets, including HO-1, NQO1, GCLC, and GCLM, prevented the production of ROS and LDH and upregulated the level of GPX4 in renal mesangial cells (Fig