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Tevimbra is expected to be available in the U.S

Routine testing of vitamin B12 levels in metformin-treated patients should be considered. Because metformin often causes digestive tract upset, many patients are also put on a proton pump inhibitor (PPIs) such as esomeprazole ( Nexium ), lansoprazole ( Prevacid ) or omeprazole ( Prilosec )

This approach is mainly indicated for lesions involving less than 90 of the bowel circumference and 3 cm in length (with double discoid excision feasible for larger lesions ~5 cm), aiming to reduce morbidity compared to segmental resection while maintaining similar recurrence rates

(2021) "MOTS-c reduces myostatin and muscle atrophy in aged mice." Published in Aging Cell