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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

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The need to consider the impacts of microplastics under different environmental conditions, multiple stressors, and intrinsic factors of fish has been extensively discussed and emphasized (Parker et al., 2021)

In terms of genomic instability, gain-of-function mutations of proto-oncogenes (e.g., KRAS, 10 BRAF, 11 EGFR 12 and ERBB2 13 ), loss-of-function mutations of tumor suppressor genes (e.g., TP53, 14 PTEN 15 and APC 16 ), and defects in DNA damage repair genes (e.g., BRCA1/2, 17 MSH2 and MLH1 18 ) have been reported to drive tumorigenesis in a number of cancer types