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"Vitamin C." National Institutes of Health: Office of Dietary Supplements

However, direct clinical evidence demonstrating this causal sequence in patients remains limited and warrants further validation using in vivo or ex vivo barrierfunction assays

Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

Rouar, T., Parik, P., Kucera, O., Barto, M