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Finally, AST is a highly lipophilic carotenoid with low and formulation-dependent oral bioavailability

In fact, cationic LNPs can directly interact with the negatively charged DNA, allowing them to safely protect genetic materials and facilitating effective gene transfection into cells, which makes LNPs a promising system for gene delivery [196, 197]

2.9 Single-cell transcriptomic analysis To investigate the expression patterns of key genes across different cell types and their dynamic changes within the RA immune microenvironment, the GSE159117 dataset was downloaded from the GEO database and subjected to systematic single-cell transcriptomic analysis